- Brown Family Papers, 1825/1965, bulk 1850/18941
- Carrie T. Sibold Family Papers, 1912/1990, bulk 1974/19901
- Charles A. Miller Family Papers, 1708/19261
- Charles W. Crush Collection, 1796/19781
- Charlton Family Papers, 1853/19581
- Christiansburg [Virginia] Industrial Institute Historical Documents, 1866/19911
- Civil War Small Manuscripts Collection, 1861/19961
- Croy Family Papers, 1859/19381
- Dorothy H. Bodell Papers, 1850/19961
- Earhart Family Papers, 1788/19281
- Earl Palmer Appalachian Photograph and Artifact Collection, 1880/19891
- Elizabeth Kent Adams Papers, 1922/19871
- Ellett Family Papers, 1865/19611
- Ellison A. Smyth, Jr. Papers,, 1859/19271
- Emmett Russell Price Scrapbooks, 1910/19431