- Charles A. Miller Family Papers, 1708/19261
- Charles W. Crush Collection, 1796/19781
- Charlton Family Papers, 1853/19581
- Christiansburg [Virginia] Industrial Institute Historical Documents, 1866/19911
- Civil War Small Manuscripts Collection, 1861/19961
- Croy Family Papers, 1859/19381
- Detail Sketch of V.P.I. Campus, 19081
- Doctor V. Jewell Account Books, 1898/19231
- Dorothy H. Bodell Papers, 1850/19961
- Earhart Family Papers, 1788/19281
- Earl Palmer Appalachian Photograph and Artifact Collection, 1880/19891
- Ellett Family Papers, 1865/19611
- Ellison A. Smyth, Jr. Papers, 1859/19271
- Gardner Family Papers, 1889/19371
- George Green Shackelford Papers, 1899/1990, bulk 1955/19891