- Black, Kent, and Apperson Family Papers, 1779/19841
- Brown Family Papers, 1825/1965, bulk 1850/18941
- Daniel E. Wright Papers, 1903/19731
- Daniel Hale, Physician and Conservationist, Papers, 1953/19751
- Elden E. Billings Collection, 1862/19911
- George S. Goldstein, Health Care Administrator, Records regarding United Mine Workers of America Health and Retirement Funds, 1950/19961
- Guy Di Carlo, Jr., Civil War Research Papers, 1862/20021
- John Harville Diaries, 1861/2010, bulk 1861/18641
- Piedmont Tuberculosis Sanatorium (Burkeville, Virginia) Collection, 1926/19711
- Squire Bosworth, Physician, Papers, 1786/19641
- West Virginia University, Medical Education History, Research Notes, 1869/19641
- William M. Bickers Papers, 1960/19701