- Daniel Crump Buchanan Papers, 1935/19571
- Davidson Family Papers, 1830/19151
- Douglas Southall Freeman Manuscript, 19461
- Dr. and Mrs. Wyatt Tee Walker collection, 1953/20161
- Dunlap Family Papers, 1830/18782
- E. P. Conkle papers, 1928/19941
- Edward H. Peple Collection, 1891/19531
- Edwin L. Dooley, Jr. collection, 1986/19981
- Fairfax-Spencer family recipe book, 1694/17951
- Fred F. Finklehoffe papers, 1928/19501
- French handwritten music manuscript, 17461
- George P. C. Rumbough commencement speech manuscript, 18561
- Halford Ross Ryan Papers, 1985/19931
- Henry Ruffner collection, 1815/18671
- Illuminated manuscript leaf1