- "A Quarter of a Century in Medicine" by Dr. J.W.C. Cuddy handwritten manuscript, 18881
- "An Alarm to the frequenters of Plays, wrote by a Religious Person" handwritten broadside, 17741
- "Three solos for the violoncello with accompaniment for a bass" by Johan Arnold Dahmen music manuscript, 17941
- "We Were Not Shadows" by Colonel E.P.J. Ryan, O.B.E typed manuscript, 1955/19651
- A Confederate Woman's Civil War Journal, 1860/18661
- Abraham Anson papers, 1939/20051
- Alfred Leyburn Papers, 1823/1899, bulk 1830/18391
- Andrew C. L. Gatewood papers, 1860/19932
- Arthur Herman papers1
- Bernard G. Hoffman ethnohistory papers, 1953/19641
- Charles H. Carson papers, 1800/19001
- Chester F. Burgess collection, 19661
- Colin F. McClare papers, 1960/19701
- Cook family homemade music manuscript1
- Dabney Stuart Papers, 1989/2009, bulk 2000/20091