- A. J. Davis Family Collection, 1874/2007, bulk 1874/19071
- Alleghany Chapter, National Society of the Daughters of the American Revolution Records,, 1890/20221
- Blacksburg Baptist Church Records, 1894/20071
- Carter/Cash Family Collection, 1940/20091
- Elizabeth Fine Papers, 1983/20121
- Hard Times Blues Collection, 1966/20191
- Hardwick Family Correspondence, 20071
- J. Hoge Tyler Diary, 1846/2009, bulk 1846/19251
- John M. and Cora Bolton McBryde Family Papers, 1862/20181
- Lucy Herndon Crockett Papers,, 1940/20151
- Madison E. Marye Papers, 1932/20071
- Margaret M. Sullivan Collection, 1932/20111
- Milka T. Bliznakov Papers and Architectural Drawings, 1946/20101
- New River Community Action, Inc., Records, 1966/20151
- Peacock-Harper Culinary History Friends Records, 1999/20191