- A. J. Davis Family Collection, 1874/2007, bulk 1874/19071
- Alleghany Chapter, National Society of the Daughters of the American Revolution Records, 1890/20221
- Anne Price Yates Papers II, 1898/20051
- Appalachian History Films, 1981/20051
- Appalachian Regional Commission Teaching Project Records, 2001/20061
- Benjamin Huddle Diary, 1861/20061
- Blacksburg Baptist Church Records, 1894/20071
- Blacksburg Electronic Village Collection, 1992/20061
- Carter/Cash Family Collection, 1940/20091
- Elizabeth Fine Papers, 1983/20121
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/19691
- Floyd Courthouse Chapter, National Society of the Daughters of the American Revolution Records, 1935/20041
- Funeral Consumers Alliance of the Virginia Blue Ridge Papers, 2001/20041
- Gary Ann Giovanni Culinary Papers, 1997/20041
- Hard Times Blues Collection, 1966/20191