- Richard B. Dickenson Papers, 1931/2004, bulk 1964/20001
- Rick Boucher Papers, 1968/2017, bulk 1975/20111
- Roanoke Appalachian Trail Club Records, 20251
- Roanoke Valley Academy of Medicine Records, 1874/20161
- Robert Creede Taylor Family Reference Collection, 2003/20061
- Southside Garden Club Records, 1914/20091
- The Reverend Dr. and Mrs. Richard Eugene Hager (Anne Peyton Judkins Hager) Collection, 1802/20071
- Thomas David Perry Collection, 1979/20071
- United Daughters of the Confederacy, Dr. Harvy Black Chapter Records, 1862/20101
- Virginia Academy of Science Records, 1920/20051
- Virginia Association of Educational Opportunity Program Personnel (VAEOPP) Records, 1970/20151
- Virginia Extension Homemakers Council Papers, 1948/20071
- Virginia Tech Buildings Architectural Collection, 1907/2011, bulk 1953/19961
- Virginia Tech Magazine, 20041
- Welford D. Taylor Collection on Sherwood Anderson, 1918/20061