- J. Hoge Tyler Diary, 1846/2009, bulk 1846/19251
- James Glanville Collection, 20041
- John M. and Cora Bolton McBryde Family Papers, 1862/20181
- Lucy Herndon Crockett Papers, 1940/20151
- Lyric Theatre Collection, 1922/2006, bulk 1922/19791
- Madison E. Marye Papers, 1932/20071
- Margaret M. Sullivan Collection, 1932/20111
- Milka T. Bliznakov Papers and Architectural Drawings, 1946/20101
- New River Community Action, Inc., Records, 1966/20151
- Newport and Clover Hollow, Giles County History Collection, 1904/20061
- Organ Family Collection, 1836/20061
- Peacock-Harper Culinary History Friends Records, 1999/20191
- Pulaski Theater Oral History Project, 2003/20041
- Randolph Family Papers, 1851/2004, bulk 1851/18651
- Records of the American Association of University Women (AAUW), Virginia Tech Chapter, 1926/20081