- Carrie T. Sibold Family Papers, 1912/1990, bulk 1974/19901
- Carter/Cash Family Collection, 1940/20091
- Christiansburg [Virginia] Industrial Institute Historical Documents, 1866/19911
- Christiansburg-Blacksburg Chapter, Rotary Club Records,, 1965/19981
- Civil War Small Manuscripts Collection, 1861/19961
- Clarence Trent Papers, 1958/19911
- Cynthia Addington Boatwright Papers, 1930/19901
- Dale Belcher Photographs, 1987/19941
- Dorothy H. Bodell Papers, 1850/19961
- Dorothy McCombs Collection,, 1970/19891
- Earl Palmer Appalachian Photograph and Artifact Collection, 1880/19891
- Edgemont Farm Papers, 1925/19981
- Elizabeth Fine Papers, 1983/20121
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/19691
- Film Footage of the State of Virginia, 1980/20031