- Charles Willis Cassell Family Papers, 1883/19501
- Charlton Family Papers, 1853/19581
- Christiansburg [Virginia] Industrial Institute Historical Documents, 1866/19911
- Civil War Small Manuscripts Collection, 1861/19961
- Civilian Conservation Corps and Family Photograph Collection, 1925/19361
- Croy Family Papers, 1859/19381
- Cynthia Addington Boatwright Papers, 1930/19901
- Devota Pack Manuscript Collection, 1858/19771
- Dillard-Larkin Family Papers, 1809/19551
- Dorothy H. Bodell Papers, 1850/19961
- Dr. Thomas' Eclectric Oil Trade Card, 1875/19401
- Earl Palmer Appalachian Photograph and Artifact Collection, 1880/19891
- Edgemont Farm Papers, 1925/19981
- Edwin Houston Harman Papers, 1856/1984, bulk 1856/18641
- Elizabeth Kent Adams Papers, 1922/19871