- Carrie T. Sibold Family Papers, 1912/1990, bulk 1974/19901
- Catlett Conway Correspondence, 1892/19201
- Chapman J. French Diaries, 1906/19441
- Charles A. Miller Family Papers, 1708/19261
- Charles E. Vawter Family Collection, 1882/19131
- Charles M. Perry Papers, 1891/19711
- Charles W. Crush Collection, 1796/19781
- Charles Willis Cassell Family Papers, 1883/19501
- Charlton Family Papers, 1853/19581
- Chilhowie Milling Company Correspondence, 1902/19171
- Christiansburg [Virginia] Industrial Institute Historical Documents, 1866/19911
- Civil War Small Manuscripts Collection, 1861/19961
- Craft Family Collection, 1861/19191
- Croy Family Papers, 1859/19381
- David S. Doggett Letters, 1912/19151