- David S. Rice Family Papers, 1857/18941
- Devota Pack Manuscript Collection, 1858/19771
- Dickinson Family Papers, 1871/19311
- Dickson Family Papers, 1769/19241
- Dillard-Larkin Family Papers, 1809/19551
- Dillon, Ellett & Company Ledgers, 1871/18991
- Dorothy H. Bodell Papers, 1850/19961
- Earhart Family Papers, 1788/19281
- Edwin Houston Harman Papers, 1856/1984, bulk 1856/18641
- Ellett Family Papers, 1865/19611
- Ellison A. Smyth, Jr. Papers, 1859/19271
- Emory M. Cox Receipts, 1862/19021
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/19691
- Fiske-Seymour Family Papers, 1864/19181
- Flora Baker Hiett Correspondence, 1854/18781