- Brown Family Papers, 1825/1965, bulk 1850/18941
- Burns & Burns Records, 1871/19101
- Charles A. Miller Family Papers, 1708/19261
- Charles W. Crush Collection, 1796/19781
- Charles W. Hardin Collection, 1847/18831
- Charlton Family Papers, 1853/19581
- Christiansburg Presbyterian Church Minute Book, 1869/18971
- Christiansburg [Virginia] Industrial Institute Historical Documents, 1866/19911
- Civil War Small Manuscripts Collection, 1861/19961
- Craft Family Collection,, 1861/19191
- Creed F. Flanary Account Books, 1871/19081
- Crowder Family Papers,, 1821/18751
- Croy Family Papers, 1859/19381
- David Cloyd McGavock Papers, 1861/19011
- David N. Walker Business Records, 1859/18981