- Shakes Letter Collection (MS005), 1778/201516
- Chapman-Southerland Collection (MS409), 1878/19136
- Sangster Papers (MS294), 1853/18916
- Royd R. Sayers Collection (MS094), 1932/19683
- Whitton Collection (MS027), 1843/19893
- Daniel O'Sullivan Collection (MS141), 1850/19122
- Thomas Swann Correspondence (MS410), 1848/18572
- Abraham Anson papers, 1939/20051
- Alexandria Antique Arts Association Collection (MS134), 1971/19991
- Anne Lewis Jones Collection (MS010), 1918/19191
- Boush/Asher Family Collection (MS234), 1856/19491
- Chapman Family Collection (MS274), 1828/19631
- George Mason letters to John Augustine Washington III, 18591
- James M. Buchanan papers, 1920/20131
- Jerome Epstein papers, 1943/19831