- Abraham Anson papers, 1939/20051
- Anne Lewis Jones Collection (MS010), 1918/19191
- Boush/Asher Family Collection (MS234), 1856/19491
- Chapman Family Collection (MS274), 1828/19631
- Chapman-Southerland Collection (MS409), 1878/19131
- George Mason letters to John Augustine Washington III, 18591
- James M. Buchanan papers, 1920/20131
- Jerome Epstein papers, 1943/19831
- John Thomas Ricketts Papers (MS071), 1787/19041
- Lewis Littlepage Holladay Letters, 1858/18911
- Lucius Bellinger Northrop Papers (MS058), 1841/18631
- McKnight, Piercy, and Jacobs Collection (MS051), 1792/19731
- Peyton Randolph Papers, 1804-18131
- Phillip Fendall Papers (MS190), 1817/18571
- Randolph H. Lytton Historical Virginia collection, 1670/20041