- Charles Grattan Price Jr. collection on Tweetsie and the Shenandoah Central Railroad, 1916/1997, bulk 1948/19561
- Charles and William Person Papers, 1900/2011, bulk 1920/19501
- Chesapeake Western Railway Company Records, 1916/19821
- Christine Hoepfner Collection on the Shenandoah National Park, 1911/20001
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19281
- Croushorn Family Rockingham Cooperative Farm Bureau Papers, 1932/19581
- Curtis West Harris and Ruth Jones Harris Papers, 1950/20121
- Daisy Bacon Papers, 1857/19861
- Davis, Kline, and Hutton Family papers, 1816/19771
- Delphine Hurst Parsons papers, 1923/1976, bulk 1923/19311
- Department of History: Raymond C. Dingledine, Jr. papers, 1950/19831
- Dudley and Rexrode Family Papers, 1873/20051
- Eldon Bowman collection of Bowman family papers, 1797/20191
- Emily Lewis Lee Papers, 1940/20061
- Ernest M. Dickerman papers, 1904/20051