- Catlett Family Papers, 1865/19211
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/19961
- Charles and William Person Papers, 1900/2011, bulk 1920/19501
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19281
- Clara L. Lawrence Papers, 1763/19391
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Daisy Bacon Papers, 1857/19861
- Daisy Crisler Papers, 1904/19141
- Davis, Kline, and Hutton Family papers, 1816/19771
- Dudley and Rexrode Family Papers, 1873/20051
- Eldon Bowman collection of Bowman family papers, 1797/20191
- Elizabeth A. Wenger Papers, 1884/19511
- Ernest M. Dickerman papers, 1904/20051
- Flora Adams Darling papers, 1862/1908, bulk 1890/19081
- Frank D. Baldwin Letter and Biography, 1902/20111