- A. D. Lough correspondence, 1902/19201
- Barnhart Family Papers, 1836/19441
- Bettie E. Miller Stoutamyer papers, 1866/19151
- Bettie Hiter Willis Papers, 1864/19421
- Blackley Family papers, 1830/20201
- Brown Family papers, 1872/19191
- Catlett Family Papers, 1850/1933, bulk 1901/19291
- Charles F. Hulvey papers, 1888/19401
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/19961
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19281
- Daisy Bacon Papers, 1857/19861
- Davis, Kline, and Hutton Family papers, 1816/19771
- Dudley and Rexrode Family Papers, 1873/20051
- Eldon Bowman collection of Bowman family papers, 1797/20191
- Elizabeth A. Wenger Papers, 1884/19511