- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/19961
- Charles Jackson Letter Books, 1890/19041
- Charles and William Person Papers, 1900/2011, bulk 1920/19501
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19281
- Clara L. Lawrence Papers, 1763/19391
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Craig Family Papers, 1860/1906, bulk 1860/18801
- Daisy Bacon Papers, 1857/19861
- Davis, Kline, and Hutton Family papers, 1816/19771
- Dudley and Rexrode Family Papers, 1873/20051
- Eldon Bowman collection of Bowman family papers, 1797/20191
- Elizabeth A. Wenger Papers, 1884/19511
- Flora Adams Darling papers, 1862/1908, bulk 1890/19081
- Gallaher and Briscoe Family Confederate Papers, 1858/19251
- Geddy-Harris Archive Records, 1773/1959, bulk 1890/19401