- 1st New York Mounted Rifles letter, 18641
- Allen-Kean-Laurence family letters, 1837/19601
- Andrew J. Weeks Papers, 1861/1902, bulk 1862/18661
- Autographs of Virginians, 1846/19081
- Barnhart Family Papers, 1836/19441
- Bettie Hiter Willis Papers, 1864/19421
- Blackley Family papers, 1830/20201
- Booton-Modesitt Family Papers, 1809/1880, bulk 1820/18501
- Brown Family Papers, 1836/19081
- Catlett Family Papers, 1850/1933, bulk 1901/19291
- Charles Spitzer Letters, 1833/18861
- Christopher Columbus Collection, 1849/18801
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19281
- Clara L. Lawrence Papers, 1763/19391
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421