- Allen-Kean-Laurence family letters, 1837/19601
- Autographs of Virginians, 1846/19081
- Barnhart Family Papers, 1836/19441
- Blackley Family papers, 1830/20201
- Booton-Modesitt Family Papers, 1809/1880, bulk 1820/18501
- Brown Family Papers, 1836/19081
- Catlett Family Papers, 1850/1933, bulk 1901/19291
- Charles Spitzer Letters, 1833/18861
- Christopher Columbus Collection, 1849/18801
- Clara L. Lawrence Papers, 1763/19391
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Cushing Family Papers, 1843/18941
- Davis, Kline, and Hutton Family papers, 1816/19771
- Edward C. Dyer Papers, 1848/1865, bulk 1853/18651
- Eldon Bowman collection of Bowman family papers, 1797/20191