- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301
- Harrisonburg-Rockingham Historical Society Collection, 1740/19501
- Heatwole Family Papers, 1838/20011
- Henkel Family Papers, 1801/20081
- Henry Alexander Scammel Dearborn Papers, 1822/18501
- Henry Waring Latane Lewis family papers, 1826/18931
- Hooke family letters, 1845/18491
- James Madison Memorabilia, 1796/19511
- John "Jack" Fitzgerald Papers, 1827/18551
- John H. Grabill Papers, 1843/1981, bulk 1894/19221
- John T. Harris papers, 1771/1937, bulk 1850/19001
- Liskey Collection of Heavner Family Papers, 1788/19671
- Manley Family papers, 1707/19531
- Margaret B. Burruss Collection of Scott and Saufley Family Papers, 1786/19121
- Margaret Grattan Weaver collection, 1707/1992, bulk 1857/19101