- Lassiter Papers, 1861/19281
- Legal Documents, 1742/18951
- Lottie V. Clark Papers, 1849/19151
- Manley Family papers, 1707/19531
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Marianne L. Garber Collection of Shenandoah Valley Documents, 1780/18991
- Mary and Hannah Gibbons Papers, 1743/18901
- Maupin-Washington Papers, 1732/19321
- Maury Family papers, 1777/19771
- McAden-Hicks Papers, 1859/18981
- McGavock Family Papers, 1760/18881
- Mills E. Godwin, Jr. Papers, 1712/1989, bulk 1947/19891
- Mongle-Hughes Papers, 1832/19161
- Mr. and Mrs. James Hoover Collection of Strickler Family Papers, 1770/19631
- Mrs. Wayne Chatfield-Taylor Collection, 1825/18961