- Calfee Family Papers, 1812/1919, bulk 1859/18891
- Campbell Family Papers II, 1795/19451
- Campbell Family Papers, 1726/19201
- Carter Braxton Collection, 1833/1922, bulk 1833/18371
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Chappelear Collection, 1788/19591
- Charles Brown Papers, 1792/18881
- Charles H. Bell Papers, 1772/1929, bulk 1852/18751
- Clarence P. Jones, Jr. Papers, 1773/1915, bulk 1809/18211
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18391
- Conway Whittle Papers, 1773/1911, bulk 1801/18671
- Dangerfield Lewis papers, 1799/18541
- Daniel Philippe Aunspaugh Papers, 1800/18811
- Daniel Stickley Papers, 1829/19121