- Legal Documents, 1742/18952
- Anderson Family papers, 1755/19581
- Andrew Lindamood papers, 1768/18171
- Austin-Twyman Papers, 1765/19391
- Baird Family Papers, 1656/1922, bulk 1656/18481
- Blair Family Papers, 1741/17921
- Brafferton Estate Collection, 1691/19351
- C. L. Worthington Papers, 1752/19381
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Campbell Family Papers, 1726/19201
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Charles H. Bell Papers, 1772/1929, bulk 1852/18751
- Clarence P. Jones, Jr. Papers, 1773/1915, bulk 1809/18211
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18391