- George Washington collection, 1654/179914
- Alexander M. Davis Papers, 1850/18921
- Anderson Benskin Smith, Sr. Ledgers, 1916/1938, bulk 1916/19361
- Audie Scott Tilghman papers, 1925/19301
- Barnhart Family Papers, 1836/19441
- Basic City Mining, Manufacturing, and Land Company Records, 1890/18921
- Booton-Modesitt Family Papers, 1809/1880, bulk 1820/18501
- Cabaniss Family Papers, 1800/18371
- Campbell Family Papers, 1726/19201
- Charles Brown Papers, 1792/18881
- Charles Colfelt Papers, 1856/18771
- Charles H. Brown Financial Papers, 1860/18701
- Cocke Papers, 1838/18851
- Dixon Brothers Papers, 1846/18731
- Dr. and Mrs. Wyatt Tee Walker collection, 1953/20161