- Alexander M. Davis Papers, 1850/18921
- Anderson Benskin Smith, Sr. Ledgers, 1916/1938, bulk 1916/19361
- Booton-Modesitt Family Papers, 1809/1880, bulk 1820/18501
- Cabaniss Family Papers, 1800/18371
- Campbell Family Papers, 1726/19201
- Charles Brown Papers, 1792/18881
- Charles Colfelt Papers, 1856/18771
- Charles H. Brown Financial Papers, 1860/18701
- Cocke Papers, 1838/18851
- Dixon Brothers Papers, 1846/18731
- Dromgoole Family Papers, 1821/1896, bulk 1850/18901
- Francis Scott Key Papers, 1779/18421
- Frederick August Mayo invoice, 18311
- Harper, Hardy & Co. Invoice Book, 18401
- Henkel Family Papers, 1783/18741