- Eldon Bowman collection of Bowman family papers, 1797/20191
- Garber and Logan family papers, 1846/19491
- Gordon W. Miller Collection on Gabriel Thomas Barbee, 1787/20051
- Heatwole Family Papers, 1838/20011
- Henkel Family Papers, 1783/19101
- Henkel Family Papers, 1801/20081
- James Madison Memorabilia, 1796/19511
- John T. Harris papers, 1771/1937, bulk 1850/19001
- Manley Family papers, 1707/19531
- Margaret Grattan Weaver collection, 1707/1992, bulk 1857/19101
- Mr. and Mrs. James Hoover Collection of Strickler Family Papers, 1770/19631
- Stephens and Yount Family Papers, 1812/19951
- Thompson Family Papers, 1869/19441
- Wine Family Papers, 1885/20011