- Byers Family Papers, 1806/19291
- C. L. Worthington Papers, 1752/19381
- Cabaniss Family Papers, 1800/18371
- Calfee Family Papers, 1812/1919, bulk 1859/18891
- Campbell Family Papers II, 1795/19451
- Campbell Family Papers, 1726/19201
- Carpenter Papers, 1765/19221
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Charles Brown Papers, 1792/18881
- Charles Carroll papers, 1770/18261
- Christopher Tompkins Papers, 1778/18381
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18391
- Cornelius Nash Papers, 1808/18301
- Cornelius Smith Papers, 1805/18901