- Andrew Lindamood papers, 1768/18171
- Archibald Woods Papers, 1777/1846, bulk 1783/18461
- Armistead-Cocke Papers, 1680/19171
- Benjamin Layman Papers, 1752/18151
- Blair, Banister, Braxton, Horner, Whiting Papers, 1760/1890, bulk 1765/18171
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Borland Family Papers, 1771/19401
- Brafferton Estate Collection, 1691/19351
- C. L. Worthington Papers, 1752/19381
- Campbell Family Papers, 1726/19201
- Carpenter Papers, 1765/19221
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Charles Carroll papers, 1770/18261
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18391