- Armistead-Cocke Papers, 1680/19171
- Benefactions of Francis Nicholson, Esqr. to the Church & Clergy in North America, 1689/17041
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Carter Family Papers, 1667/1862, bulk 1792/18611
- Collection of Spanish Language Manuscripts, 1551/18581
- Dunmore Family Papers (I) [in part photocopies], 1650/18991
- John Garland Pollard Papers, 1683/1968, bulk 1856/19371
- Manuscripts - People and Family Names, 1621/1949, bulk 18001
- Robb-Bernard Papers, 1665/1980, bulk 1850/19501
- Thomas G. and Louise Rowe Pullen Collection, 1655/17911
- Tucker-Coleman papers, 1664/1945, bulk 1770/19071
- Upshur Family Papers, 1662/19361
- Virginia Cities Collection, 1663/19801
- Virginia Counties Collection, 1600/2000, bulk 1730/18901