- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Craig L. Brians Papers, 1992/20131
- Doris Zallen Papers, 1952/20161
- Elizabeth Fine Papers, 1983/20121
- Hard Times Blues Collection, 1966/20191
- Henry H. Bauer Papers, 1950/20101
- James I. Robertson Jr. Papers, 1849/20111
- Janet Johnson Collection, 1948/20221
- Jean Elliott Papers, 1999/20151
- John M. and Cora Bolton McBryde Family Papers, 1862/20181
- Larry McBryde Collection on the John McLaren McBryde Family, 1859/20131
- Milka T. Bliznakov Papers and Architectural Drawings, 1946/20101
- Records of the Department of Philosophy and Religion and Department of Religion and Culture, 1960/20161
- Records of the Office of the Dean of Virginia Tech Carilion School of Medicine, Cynda Ann Johnson, 2008/20181
- Records of the Virginia Tech Board of Visitors, 1873/20091