- Alfred C. Payne Collection, 1917/20031
- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Black Women at Virginia Tech Oral History Project Records, 1967/2000, bulk 1994/20001
- C. David Loeks Papers, 1947/19971
- Charles Goodsell Collection, 1982/20011
- College of Education Restructuring Records, 1979/19961
- Curtis W. Roane History of Plant Pathology in Virginia and Biographies of Plant Pathologists Papers, 1993/19991
- Dan H. Pletta Papers, 1942/19961
- Dean Carter Papers, 1950/2003, bulk 1964/19821
- Doris Zallen Papers, 1952/20161
- Dr. Richard Zallen Papers, 1940/20071
- Earl A. Thornton Papers, 1885/20001
- Edgemont Farm Papers, 1925/19981
- Elizabeth Fine Papers, 1983/20121
- G. Burke Johnston Papers, 1900/19931