- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Charles E. Vawter Family Collection, 1882/19131
- Diploma Collection, 1877/19641
- Ellison A. Smyth, Jr. Papers,, 1859/19271
- Harvey Lee Price Papers, 1853/19491
- Horatio Seymour Stahl Papers, 1881/19371
- James H. Lane Research Collection, 1865/19911
- James I. Robertson Jr. Papers, 1849/20111
- Jean Haskell-Speer Papers, 1782/1995, bulk 1983/19931
- John M. and Cora Bolton McBryde Family Papers, 1862/20181
- John Murray Papers, 1883/19991
- Larry McBryde Collection on the John McLaren McBryde Family, 1859/20131
- Leslie Wallace Jerrell Papers, 1881/18981
- Marshall W. Fishwick Collection, 1700/2007, bulk 1923/20071
- O'Shaughnessy Family Papers, 1857/19651