- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Ellison A. Smyth, Jr. Papers,, 1859/19271
- Harvey Lee Price Papers, 1853/19491
- James H. Lane Papers, 1874/18801
- James H. Lane Research Collection, 1865/19911
- James I. Robertson Jr. Papers, 1849/20111
- Jean Haskell-Speer Papers, 1782/1995, bulk 1983/19931
- John M. and Cora Bolton McBryde Family Papers, 1862/20181
- Larry McBryde Collection on the John McLaren McBryde Family, 1859/20131
- Marshall W. Fishwick Collection, 1700/2007, bulk 1923/20071
- O'Shaughnessy Family Papers, 1857/19651
- Ralph Minthorne Brown Papers, 1872/19471
- Records of the Virginia Tech Board of Visitors, 1873/20091
- William Bradford Alwood Collection, 1854/19271