- Adam Empie Papers, 1811/2004, bulk 1811/18501
- Chapin-Horowitz Cynogetica Collection, 1836/20141
- Galen W. Ewing Papers, 1840/1938, bulk 1840/19381
- James Madison, Sr. Papers, 1792/19311
- Julius J. Lankes Collection, 1917/19861
- Morecock Collection, 1881/19371
- Office of the President. Lyon Gardiner Tyler Records, 1888/19351
- Print Collection, 1740/19401
- Richard G. Joynt Collection of British Manuscripts, 1593/20151
- Robert E. Lee Papers, 1829/19371
- Virginia Cities Collection, 1663/19801