- James Howard Patterson Diaries, 1904/19441
- James Z. McChesney Papers, 1853/19591
- John Smith, Methodist Circuit Rider, Journal, 1786/19631
- John W. Davis, Lawyer, Papers, 1842/19781
- Joseph McGill, Diary of a Coal Mine Surveyor and Engineer, 1854/1987, bulk 1854/18561
- Logan Osborne Family and Business Records, 1761/19821
- Margaret M. Simon, Compiler, "Trips from Ohio to New Germany in Preston County, Virginia 1826, 1833, 1835", 1825/19861
- Margaret Prescott Montague, Author, Papers, 1893/19581
- Max Mathers Collection Papers, 1821/19571
- Maxwell Family Papers, 1845/2017, bulk 1845/19501
- Nicholas Marmion, Physician, Family Papers, 1798/19511
- Pauline Morehead Ash, Collector, Papers, 1855/19471
- Roy Bird Cook (1886-1961), Collector, Tavenner Family Papers and Other Material, 1772/1955, bulk 1855/18661
- Roy Bird Cook, Collector, Tavenner Family Papers and Other Material, 1778/1953, bulk 1819/18841
- Siler Family Papers, 1848/19681