- R.S. Rudd (b.1846) Records, 1839/19121
- Richard Beto, Collector, Records regarding the Civil War in West Virginia, 1861/1875, bulk 1861/18631
- Roy Bird Cook (1886-1961), Collector, Tavenner Family Papers and Other Material, 1772/1955, bulk 1855/18661
- Roy Bird Cook, Collector, Tavenner Family Papers and Other Material, 1778/1953, bulk 1819/18841
- Sarah Morgan McKown Diaries, 1860/18991
- Siler Family Papers, 1848/19681
- Snyder Family Papers, 1790/19371
- Storer College Correspondence, Business Papers and Other Material, 1854/19641
- Sweet Springs Hotel Records, 1860/19171
- T.B. Camden Papers, 1862/19071
- Welton Family Papers, 1770/19281
- William B. Curtis (1821-1891) Papers, 1830/19541
- William E. Brooks (1875-1960), Collector, Papers, 1825/19441
- William Earle Rumsey, Entomologist and Photographer, Papers, 1806/1961, bulk 1880/19371
- William H. Newcomb (b.1870) Papers, 1865/19311