- Ritchie-Harrison Papers, 1807/1938, bulk 1830/18701
- Robb-Bernard Papers, 1665/1980, bulk 1850/19501
- Robert Morris Diary, 1845/18481
- Robert Seager Collection, 1840/1887, bulk 1840/18601
- Robert Skipwith Diaries, 1834/18981
- Roy Bird Cook (1886-1961), Collector, Papers, 1679/1984, bulk 1840/19601
- Silas Totten Papers, 1845/19161
- Stephens and Yount Family Papers, 1812/19951
- Travel Diary, 1830/18601
- Tucker-Coleman papers, 1664/1945, bulk 1770/19071
- Tyler Family Papers, Group A, 1716/19461
- Tyler Family Papers, Group G, 1645/19171
- Waitman T. Willey Papers, 1820/19171
- Wasson-Cox Diary, 1826/1946, bulk 1826/18531
- West-Callis family papers, 1825/20201