- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19744
- Chappelear Collection, 1788/19591
- Hart collection, 1762/19391
- Henkel Family Papers, 1801/20081
- J. E. R. Lightfoot Grocery daybook, 1913/19261
- Langdon T. Hankins Daybook and Ledger, 1921/19301
- Linville scrapbook and daybook, 1883/2013, bulk 1883/18931
- Morton Genealogy Collection, 1830/19781
- Scott and Gunnell family papers, 1772/19901
- Shenandoah Valley miscellaneous ledgers, minute books, and registers, 1804/19331
- Spring Creek Mill daybook, 1921/19231
- Virginia Counties Collection, 1600/2000, bulk 1730/18901