- Benjamin Pennybacker Daybook, 1818/18211
- Chappelear Collection, 1788/19591
- Daniel Philippe Aunspaugh Papers, 1800/18811
- Floyd J. Whitehead Papers, 1808/18881
- Galt Papers (I), 1745/18921
- Hart collection, 1762/19391
- Henkel Family Papers, 1801/20081
- Hodgson-Estes Family Papers, 1805/18741
- Joseph Entler Account Books, 1821/18571
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19741
- Robert H. and Lorraine Strickler Collection of John Zigler Daybooks, 1816/19031
- Samuel B. Finley Account Books, 1802/18591
- Scott and Gunnell family papers, 1772/19901
- Shenandoah Valley miscellaneous ledgers, minute books, and registers, 1804/19331
- Virginia Counties Collection, 1600/2000, bulk 1730/18901