- Alexander Lockhart Nelson papers, 1848/19021
- Anderson Family papers, 1755/19581
- Anne Carter Lee Records, 1993/19941
- Campbell Family Papers, 1843/19501
- Collection of research materials about William R. Clark, 1950/20081
- Daniel Harvey Hill letter to Phelps Collins, 18491
- David Lawrence Hopkins Papers, 1861/18651
- Edmondson Family Papers, 1861/19041
- Edwin A. Pratt Correspondence, 18801
- Fix Family Papers, 1830/19241
- Francis Thomas Anderson Junkin Papers, 1910/19131
- Irwin Taylor Sanders Papers, 1925/19501
- James S. Moffatt Papers, 1941/19441
- John Alexander Graham Papers, 1910/1947, bulk 1915/19471
- Reverend Samuel Houston correspondence, 1821/18361