- David L. Holmes Papers, 1974/20111
- Dean of Arts and Sciences records, 1926/20121
- Department of History records, 1959/20231
- Dulles Corridor Rail Association records, 1985/20111
- Earl Gregg Swem Library records, 1920/20241
- Effinger School Collection, 1909/20111
- Elizabeth Cramer LGBT activism collection, 1991/20131
- F.H.C. Society Collection, 1911/20121
- Ferguson Seminar in Publishing Records, 1970/20091
- Filipino American Student Association (FASA) records, 1991/20131
- Frank Shatz Papers, 1965/20221
- George Mason University Office of the President records, 1949/20131
- Glenn Close Papers, 1966/2013, bulk 1980/19951
- Henry Clay Deshields Collection, 1861/20161
- Hickory Neck Church records, 1721/20241