- Administration records collection, 1776/19761
- Armistead Boothe Papers (MS164), 1803/19901
- Baer Family Papers, 1744/19291
- Cazenove Family Papers (MS212), 1786/19701
- Cazenove and Co. Ledger (MS293), 1857/18611
- Daniel O'Sullivan Collection (MS141), 1850/19123
- Esther Holliday Green Collection (MS073), 1859/19821
- Goss family papers, 1820/2014, bulk 1820/19301
- Historic manuscript collection, 1601/19331
- Jefferson Society records, 1825/20181
- Molly Elliot Seawell Papers, 1859/2001, bulk 1889/19161
- Robert H. and Lorraine Strickler Collection of John Zigler Daybooks, 1816/19031
- Samuel Shacklett Store Daybooks, 1845/18661
- Shakes Letter Collection (MS005), 1778/20151
- Shenandoah Valley miscellaneous ledgers, minute books, and registers, 1804/19331