- Aaron Harmon Collection (MS249), 1815/18361
- Administration records collection, 1776/19761
- Armistead Boothe Papers (MS164), 1803/19901
- Baer Family Papers, 1744/19291
- Cazenove Family Papers (MS212), 1786/19701
- Goss family papers, 1820/2014, bulk 1820/19301
- Hoak Ledger, 1794/18551
- Jefferson Society records, 1825/20181
- Robert H. and Lorraine Strickler Collection of John Zigler Daybooks, 1816/19031
- Shakes Letter Collection (MS005), 1778/20151
- Shenandoah Valley miscellaneous ledgers, minute books, and registers, 1804/19331