- Adam Empie Papers, 1811/2004, bulk 1811/18501
- Bozarth Family Papers, 1931/1985, bulk 1931/19621
- Chesapeake Western Railway Company Records, 1916/19821
- Collection of the Hulver Family and Baughman Settlement, Hardy County, West Virginia, 1800/2013, bulk 1830/19501
- Elizabeth "Libby" Custer Papers, 1930/19971
- Hall Family Papers, 1810/20071
- Heatwole Family Papers, 1838/20011
- Henkel Family Papers, 1801/20081
- Isaac & Josiah Williams Brick Company, Account Books, 1844/19901
- Ivy House Restaurant Records, 1906/1985, bulk 1948/19601
- Kappa Delta Pi. Alpha Chi Chapter Records, 1923/19861
- Marshall-Wythe School of Law Library records, 1973/19801
- Maxwell Family Papers, 1845/2017, bulk 1845/19501
- New Monmouth Presbyterian Church records, 1776/19941
- Office of the Bursar Records, 1739/19871