- Adam Empie Papers, 1811/2004, bulk 1811/18501
- Alexander Haight family collection, 1764/19761
- Amos Koontz Papers I, 1809/1965, bulk 1936/19651
- Andrew Jackson Dadisman (1881-1965), Agricultural Economics Professor, Papers, 1914/19631
- Arthur I. Boreman Papers, 1830/19491
- Association of Women Students, Minute Books, 1927/19661
- Bell Hospital Records, 1926/19701
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Bozarth Family Papers, 1931/1985, bulk 1931/19621
- Carleton Custer Pierce (1877-1958) Papers, 1840/19551
- Chappelear Collection, 1788/19591
- Charles Brinkman, Collector, Papers, 1852/19521
- Chesapeake Western Railway Company Records, 1916/19821
- Clarence Edwin Smith (1885-1959) Papers, 1787/19572
- David B. Reger, Geologist, Records, 1931/19571