- Adam Empie Papers, 1811/2004, bulk 1811/18501
- Amos Koontz Papers I, 1809/1965, bulk 1936/19651
- Austin-Twyman Papers, 1765/19391
- Bell Hospital Records, 1926/19701
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Bozarth Family Papers, 1931/1985, bulk 1931/19621
- Chappelear Collection, 1788/19591
- Davis and Bower City Meat Market (Charleston, Ill.) Account Book, 1875-1878, 1875/19781
- Diggs Family Papers, 1914/1960, bulk 1920/19401
- George Smith Papers, 1862/19541
- Hall Family Papers, 1810/20071
- Henry Denison Cole Papers, 1786/19391
- Ivy House Restaurant Records, 1906/1985, bulk 1948/19601
- James City County and City of Williamsburg Personal Property Tax Books, 1865/19491
- John Millington Papers, 1801/19511