- Adam Empie Papers, 1811/2004, bulk 1811/18501
- Alexander Haight family collection, 1764/19761
- Amos Koontz Papers I, 1809/1965, bulk 1936/19651
- Anderson Benskin Smith, Sr. Ledgers, 1916/1938, bulk 1916/19361
- Andrew Jackson Dadisman (1881-1965), Agricultural Economics Professor, Papers, 1914/19631
- Arthur I. Boreman Papers, 1830/19491
- Association of Women Students, Minute Books, 1927/19661
- Austin-Twyman Papers, 1765/19391
- Bayles Family Papers, 1827/19451
- Bell Hospital Records, 1926/19701
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Bozarth Family Papers, 1931/1985, bulk 1931/19621
- C. L. Worthington Papers, 1752/19381
- Carleton Custer Pierce (1877-1958) Papers, 1840/19551
- Chappelear Collection, 1788/19591